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KMID : 0387920050160020093
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Korean Journal of Cytopathology
2005 Volume.16 No. 2 p.93 ~ p.97
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Touch Imprint Cytology of Merkel Cell Carcinoma - A Case Report -
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Kim Lucia
Park In-Suh
Han Jee-Young
Kim Joon-Mee
Chu Young-Chae
Choi Suk-Jin
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Abstract
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Merkel cell carcinoma (MCC) is a rare primary cutaneous neuroendocrine carcinoma which commonly presents as a skin nodule, and can develop into regional lymph node metastases, as well as spread systematically. Here, we describe the cytological features of a touch imprint of MCC that arose on the face of a 62-year-old female. This touch imprint was acquired from an incisional biopsy specimen which had been submitted for frozen section. The touch preparation produced a highly cellular imprint of loosely cohesive groups of small- to medium-sized malignant cells exhibiting uniform round to oval nuclei, delicate nuclear membranes, fine chromatin, small nucleoli, and scanty cytoplasm, with occasional paranuclear button-like inclusions. We applied cytokeratin 20 to the touch imprint for immunochemistry, allowing us to visualize the tumor cells with paranuclear dot-like positivity. Both the cytological and immunocytological features were quite distinct.
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KEYWORD
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Merkel cell carcinoma, I mprint, Cytology, Neuroendocrine carcinoma, Skin
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